What is the Ambroxol hydrochloride?

Ambroxol hydrochloride is white crystalline powder, while it's Molecular Formula is C13H19Br2ClN2O. white crystalline powder Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy. Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. It enhances pulmonary surfactant production and stimulates ciliary activity.

What is the CAS number for Ambroxol hydrochloride?

The CAS number of Ambroxol hydrochloride is 23828-92-4.

Product Class

23828-92-4

Product Name：Ambroxol Hcl
Molecular Formula：C₁₃H₁₉Br₂ClN₂O
Purity：99%
Molecular Weight：414.568

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Product Details:

CasNo： 23828-92-4

Molecular Formula： C₁₃H₁₉Br₂ClN₂O

Appearance： white crystalline powder

Wholesale Quality Manufacturer Supply Ambroxol Hcl 23828-92-4 Efficient Shipping

Molecular Formula:C13H19Br2ClN2O
Molecular Weight:414.568
Appearance/Colour:white crystalline powder
Vapor Pressure:1.61E-10mmHg at 25°C
Melting Point:233-234.5 °C
Boiling Point:468.6 °C at 760 mmHg
Flash Point:237.2 °C
PSA：58.28000
Density:1.612 g/cm3
LogP:4.96100

Ambroxol Hcl(Cas 23828-92-4) Usage

Category	Expectorant, Mucolytic agent
Definition	Ambroxol hydrochloride is a mucolytic agent used to thin and loosen mucus in the respiratory tract, facilitating easier expectoration. It is a metabolite of bromhexine, known for stimulating mucociliary activity, promoting surfactant production, and improving mucus clearance in conditions with abnormal mucus secretion.
Molecular Structure	Ambroxol hydrochloride features a brominated aromatic ring and a cyclohexanol group, contributing to its mucolytic and expectorant properties.
Uses	Huarong Pharm has built platforms for the research, development and manufacturing of Building Blocks, Reference Compounds & Impurities, Natural products, APIs & Intermediates, Antibody-drug Conjugates (ADCs) and others. To maintain a high innovation efficiency, the company has continuously increased the investment on R&D facilities and state-of-the-art equipment in the past several years, including the establishment of kilogram GMP conditions plants and R&D centers. Ambroxol hydrochloride is widely used to treat conditions with abnormal mucus secretion, It aids in thinning and loosening phlegm, allowing easier expectoration and relieving symptoms such as coughing, wheezing, chest tightness, and shortness of breath. Ambroxol enhances the concentration of antibiotics (e.g., amoxicillin, erythromycin) in the lung tissue, improving their bactericidal effects. It works by breaking down mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to expel. It also increases ciliary movement and promotes surfactant production, which improves respiratory health.
Acute toxicity	Oral-rat LD50: 4203 mg kg; Oral-Mouse LD50: 2380 mg/kg.

InChI:InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

23828-92-4 Relevant articles

Concurrent analysis of ambroxol HCl and salbutamol sulphate from tablet formulation by RP-HPLC

Wrushali A. Panchale 1, Neha A. Badukle 2, Amar F. Sabhadinde 1, Ravindra L. Bakal 1 and Jagdish V. Manwar 2, *

, GSC Biological and Pharmaceutical Sciences, 2020, 13(03), 197-202.

The retention time of ambroxol HCl and salbutamol sulphate was found to be 3.61 and 6.20 min, respectively. The detection was carried out at 224 nm. The dynamic range for ambroxol HCl and salbutamol sulphate observed was 15-75 µg/ml and 1-5 µg/ml, respectively. The percent recovery obtained for ambroxol HCl and salbutamol sulphate were close to 100%. Obtained statistical data of results was found to satisfactorily.

Compatibility Study of Ambroxol HCl Drug-Excipients by Using IR Spectroscopy

Dr. Daharwal S. J.*, Jangade Rajendra K., Thakur Veena Devi, Sahu Bhanu Pratap

Asian Journal of Pharmaceutical Analysis, 2013, Volume : 3, Issue : 3

In this report FTIR studies were performed and major peaks were determined by the (FTIR-8400S Shimadzu, Japan) will show band shift and broadening compared to the spectra of pure drug. To study the interaction between AmbroxolHCl, selected excipients (sorbitol, mannitol, sucrose). IR spectra of Ambroxol hydrochloride bands were found at 1595–1545 cm−1 for aromatic C=C stretching, 3350-3250cm−1 for aromatic primary amine NH stretch, 3400–3345 cm−1 for intermolecular hydrogen bonded OH stretch and 700–600 cm−1 for C-Br stretching.

23828-92-4 Upstream products

95-53-4
o-toluidine
18683-91-5
ambroxol
861787-48-6
3,5-dibromo-2-nitro-benzaldehyde
552-89-6
2-nitro-benzaldehyde

23828-92-4 Downstream products

18683-91-5
ambroxol
15942-08-2
4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)-cyclohexanol hydrochloride
2088879-81-4
4-(6,8-dibromo-3,4-dihydroquinazolin-3-yl)cyclohexanol

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