What is the Terbinafine hydrochloride?

Terbinafine hydrochloride is Crystalline powder, while it's Molecular Formula is C21H26ClN. Crystalline powder Terbinafine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by UV spectrophotometry and high-performance thin layer chromatography (HPTLC).

What is the CAS number for Terbinafine hydrochloride?

The CAS number of Terbinafine hydrochloride is 78628-80-5.

What is Terbinafine hydrochloride (78628-80-5) used for?

Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively). Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+

What is the Terbinafine hydrochloride?

Terbinafine hydrochloride is Crystalline powder, while it's Molecular Formula is C21H26ClN. Crystalline powder Terbinafine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by UV spectrophotometry and high-performance thin layer chromatography (HPTLC).

What is the CAS number for Terbinafine hydrochloride?

The CAS number of Terbinafine hydrochloride is 78628-80-5.

What is Terbinafine hydrochloride (78628-80-5) used for?

Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively). Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+

Product Class

78628-80-5

Product Name：Terbinafine Hcl
Molecular Formula：C₂₁H₂₆ClN
Purity：99%
Molecular Weight：327.897

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Product Details:

CasNo： 78628-80-5

Molecular Formula： C₂₁H₂₆ClN

Appearance： Crystalline powder

Chinese Manufacturer Supply Top Purity Terbinafine Hcl 78628-80-5 Fast Shipping

Molecular Formula:C21H26ClN
Molecular Weight:327.897
Appearance/Colour:Crystalline powder
Vapor Pressure:3.42E-07mmHg at 25°C
Melting Point:204-208 °C
Refractive Index:1.586
Boiling Point:417.9 °C at 760 mmHg
Flash Point:183.7 °C
PSA：3.24000
Density:1.007g/cm3
LogP:5.67930

Terbinafine Hcl(Cas 78628-80-5) Usage

Category	Antifungal Drug, Allylamine Class
Definition	Terbinafine Hydrochloride (TBF-HCl) is a synthetic allylamine antifungal agent used primarily to treat superficial fungal infections of the skin and nails, particularly onychomycosis, a fungal infection of the nail plate. It inhibits fungal growth by targeting the enzyme squalene epoxidase, disrupting the fungal cell membrane.
Mechanism of Action	Terbinafine inhibits squalene epoxidase, an essential enzyme in the fungal cell membrane ergosterol biosynthesis pathway. This leads to the toxic accumulation of squalene within the cell and results in fungal cell death.
Safety Profile	Generally well-tolerated, though systemic use may cause adverse effects such as liver toxicity, gastrointestinal issues, or allergic reactions.
Uses	Huarong Pharm adheres to our vision, our mission, and our value, keeping abreast of the current trend and state-of-the-art science and technologies of the global biopharmaceutical industry to serve our clients to the utmost satisfaction. Our existing advantages have led to our in-depth services for the R&D of small molecule drug discovery. Terbinafine HCl is most commonly used to treat onychomycosis, a fungal infection that affects the nail plate, causing discoloration, thickening, and brittle nails. It is effective against fungal species such as Trichophyton, Microsporum, and Epidermophyton, which cause conditions like athlete’s foot, jock itch, and ringworm.
Brand name	Lamisil
Formulation and Efficacy:	Terbinafine HCl’s lipophilic nature and high affinity for keratin-rich tissues make it particularly effective in penetrating the skin and nails, allowing for targeted treatment of fungal infections. However, oral formulations are generally preferred for treating nail infections due to the difficulty of drug penetration through the nail plate.

InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+

78628-80-5 Relevant articles

Novel topical formulations of Terbinafine-HCl for treatment of onychomycosis

Sakine Tuncay Tanrıverdi , Özgen Özer

, European Journal of Pharmaceutical Sciences Volume 48, Issues 4–5 , 12 March 2013, Pages 628-636

Nail characterization studies were also performed to examine the effect of formulations and experimental conditions on nail surface. As a result, all formulations can serve as efficient formulations for ungual application of TBF-HCl. By the way, the results of the accumulation studies suggested that liposome poloxamer gel formulation could be promising system for ungual drug delivery due to the better accumulation and easier application of the formulation.

Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels

Murat Şen, Cengiz Uzun, Olgun Güven

International Journal of Pharmaceutics Volume 203, Issues 1–2, 1 August 2000, Pages 149-157

Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH sensitive poly(acrylamide/maleic acid) (P(AAm/MA)) hydrogels were investigated. P(AAm/MA) hydrogels were prepared by irradiating the ternary mixtures of AAm/MA/and water by γ-rays at ambient temperature.

78628-80-5 Process route

: 14489-75-9
N-methyl-1-naphthalenemethylamine

: 287471-30-1
1-chloro-6,6-dimethyl-hept-2-ene-4-yn

: 78628-80-5,176168-78-8
terbinafine hydrochloride

Conditions

Conditions	Yield
N-methyl-1-naphthalenemethylamine; 1-chloro-6,6-dimethyl-hept-2-ene-4-yn; With potassium carbonate; In water; at 80 ℃; for 4h; Large scale; With hydrogenchloride; In water; at 0 - 10 ℃; Large scale;	93%

: 14489-75-9
N-methyl-1-naphthalenemethylamine

: 78629-20-6
3-hydroxy-6,6-dimethylhept-1-ene-4-yne

: 78628-80-5,176168-78-8
terbinafine hydrochloride

Conditions

Conditions	Yield
3-hydroxy-6,6-dimethylhept-1-ene-4-yne; With hydrogenchloride; trichlorophosphate; In methanol; at 0 - 20 ℃; for 20 - 24h; N-methyl-1-naphthalenemethylamine; With sodium hydroxide; at 80 ℃; With hydrogenchloride; In dichloromethane; water; at 20 ℃;	81%