1190363-46-2
- Product Name：(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
- Molecular Formula：C25H33F2NO2Si
- Purity：99%
- Molecular Weight：445.625
Product Details:
CasNo： 1190363-46-2
Molecular Formula： C25H33F2NO2Si
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Hot Sale 1190363-46-2 Fast Shipping, Buy Reliable Quality (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one
- Molecular Formula:C25H33F2NO2Si
- Molecular Weight:445.625
- Boiling Point:477.5±45.0 °C(Predicted)
- Density:1.10±0.1 g/cm3(Predicted)
1190363-46-2 Supplier
Hangzhou Huarong Pharm Co., Ltd. is a quality factory of (6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one.
1190363-46-2 Relevant articles
Development of a scalable palladium-catalyzed α-arylation process for the synthesis of a CGRP antagonist
Desai, Lopa V.,Hay, Michael B.,Leahy, David K.,Wei, Carolyn,Fanfair, Dayne,Rosner, Thorsten,Hsiao, Yi
, p. 5677 - 5684 (2013/07/11)
The Pd-catalyzed α-arylation of cyclohep...
Efficient and scalable enantioselective synthesis of a CGRP antagonist
Leahy, David K.,Fan, Yu,Desai, Lopa V.,Chan, Collin,Zhu, Jason,Hanson, Ronald L.,Sugiyama, Masano,Rosner, Thorsten,Cuniere, Nicolas,Guo, Zhiwei,Hsiao, Yi,Luo, Guanglin,Chen, Ling,Gao, Qi
supporting information, p. 4938 - 4941,4 (2012/12/12)
An enantioselective synthesis of the CGR...
CGRP Receptor Antagonists
-
Page/Page column 31, (2009/10/21)
The disclosure generally relates to the ...
1190363-46-2 Process route
-
![(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one](/upload/2024/1/a859a83a-974c-43ba-9a83-cfb1260a5c10.png)
- 1190363-45-1
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
-
- 38573-88-5
1-bromo-2,3-difluorobenzene
-
![(6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one](/upload/2024/1/2a4a8515-4176-4ea8-a36b-12b6213396b4.png)
- 1190363-46-2
(6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one
-
![(6R,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one](/upload/2024/1/4eea8b0d-9bac-46a5-a4e1-b60f9863eaaa.png)
- 1397526-07-6
(6R,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one
| Conditions | Yield |
|---|---|
|
With sodium t-butanolate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; palladium diacetate; In toluene; at 80 ℃; for 20h;
|
71.4 % de |
|
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 95 ℃; for 4h; Overall yield = 63 %; Overall yield = 4.15 kg; Large scale;
|
84.615 % de |
|
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 95 ℃; for 4h; Reagent/catalyst; Temperature; Concentration; Overall yield = 63 %; Overall yield = 4.15 kg; Large scale;
|
84.615 % de |
-
- 1190363-45-1
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
-
- 38573-88-5
1-bromo-2,3-difluorobenzene
-
- 1190363-46-2
(6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one
| Conditions | Yield |
|---|---|
|
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one; 1-bromo-2,3-difluorobenzene; With potassium phosphate; palladium diacetate; ruphos; In tert-Amyl alcohol; at 95 ℃; Inert atmosphere;
With hydrogenchloride; In tert-Amyl alcohol; water; at 15 - 30 ℃; for 0.25h; Inert atmosphere;
With L-Cysteine; In tert-Amyl alcohol; water; at 50 ℃; for 2h; Reagent/catalyst; Solvent; Temperature; Concentration; diastereoselective reaction;
|
73% |
1190363-46-2 Upstream products
-
1190363-45-1
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
-
38573-88-5
1-bromo-2,3-difluorobenzene
-
1190363-44-0
(R)-9-hydroxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one hydrochloride
-
39713-40-1
7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione
1190363-46-2 Downstream products
-
1190363-50-8
(5S,6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]-pyridin-5-ol
-
1289023-67-1
BMS-927711
-
1397525-83-5
(5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride
-
1190363-51-9
(5S,6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-yl methanesulfonate
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