942195-86-0

  • Product Name:7-hydroxy-N,N,2-trimethyl-3-tosyl-3H-benzo[d]imidazole-5-carboxamide
  • Molecular Formula:C18H19N3O4S
  • Purity:99%
  • Molecular Weight:373.433
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Product Details:

CasNo: 942195-86-0

Molecular Formula: C18H19N3O4S

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Factory Supply High Purity 7-hydroxy-N,N,2-trimethyl-3-tosyl-3H-benzo[d]imidazole-5-carboxamide 942195-86-0 Safe Shipping

  • Molecular Formula:C18H19N3O4S
  • Molecular Weight:373.433

7-hydroxy-N,N,2-trimethyl-3-tosyl-3H-benzo[d]imidazole-5-carboxamide (Cas 942195-86-0) Usage

7-hydroxy-N,N,2-trimethyl-3-tosyl-3H-benzo[d]imidazole-5-carboxamide plays a vital role in organic synthesis, serving as a crucial building block in the creation of complex organic compounds. Its unique structure, incorporating hydroxyl, methyl, tosyl, and imidazole moieties, makes it valuable for synthesizing diverse molecular structures. The compound is particularly significant as an intermediate in the production of various pharmaceutical compounds, highlighting its role in pharmaceutical backbone materials. It acts as a key component in constructing molecular structures with potential therapeutic applications, emphasizing its importance in the pharmaceutical industry.

942195-86-0 Relevant articles

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE ACID PUMP INHIBITORS

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Page/Page column 45, (2008/06/13)

Abstract This invention relates to compo...

SPIRO BENZIMIDAZOLE DERIVATIVES AS ACID PUMP INHIBITORS

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Page/Page column 51, (2008/12/07)

This invention relates to compounds of t...

Chromane Substituted Benzimidazole Derivatives

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Page/Page column 33, (2010/11/27)

This invention relates to compounds of t...

942195-86-0 Process route

N,N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-4-[(phenylmethyl)oxyl]-1H-benzimidazole-6-carboxamide
942195-85-9

N,N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-4-[(phenylmethyl)oxyl]-1H-benzimidazole-6-carboxamide

4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide
942195-86-0

4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Conditions
Conditions Yield
With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 30h; under 760.051 Torr;
98%
With hydrogen; 10 % Pd(OH)2/C; In tetrahydrofuran; at 20 ℃; for 30h; under 760.051 Torr; Product distribution / selectivity;
98%
With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 30h; under 760.051 Torr;
98%
With hydrogen; acetic acid; palladium(II) hydroxide/carbon; for 4h; under 3040.2 Torr; Product distribution / selectivity;
36%
N-[4-bromo-2-nitro-6-(benzyloxy)phenyl]acetamide
942195-80-4

N-[4-bromo-2-nitro-6-(benzyloxy)phenyl]acetamide

4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide
942195-86-0

4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: iron; acetic acid / 6 h / Heating / reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C
2.2: 0.5 h / 0 - 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 32 h / 65 °C
3.2: 20 °C
4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 h / 20 °C / 760.05 Torr
With hydrogen; iron; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;
 

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