Product Class

2563929-84-8

Product Name：Bepirovirsen Sodium
Molecular Formula：C230H290N88Na19O115P19S19
Purity：99%
Molecular Weight：7762.00

Inquiry

Product Details:

CasNo： 2563929-84-8

Molecular Formula： C230H290N88Na19O115P19S19

Appearance： White to off-white Solid

Delivery Time： 2 weeks after order

Packing： Bottle

Throughput： 1KG/Month

Purity： 99%

Description

Bepirovirsen (ISIS 505358) sodium is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen sodium leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen sodium can be used for the research of chronic HBV infection. Bepirovirsen sodium binding site sequence (GCACTTCGCTTCACCTCTGC)^[1]^[2]^[3].

In Vitro

Bepirovirsen sodium (16-250 nM, 96 h) reduces levels of HBV RNA transcripts in HBV-expressing HepG cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bepirovirsen sodium Related Antibodies

HBsAg Antibody (YA913)

In Vivo

Bepirovirsen sodium (22 and 50 mg/kg, s.c., twice weekly for week 1 and once weekly for weeks 2-4) reduces hepatic RNA transcripts, subsequent production of HBV DNA, and associated HBV serum antigens in HBV-transgenic mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HBV-transgenic mice^[3]
Dosage:	22 and 50 mg/kg
Administration:	s.c., twice weekly for week 1 and once weekly for weeks 2-4
Result:	Dose-dependently reduced hepatic expression of HBV RNA in HBV transgenic mice and reduced levels of all cytoplasmic hepatitis B core antigen in HBV-transgenic mice.

Molecular Weight

7762.00

Formula

C₂₃₀H₂₉₀N₈₈Na₁₉O₁₁₅P₁₉S₁₉

CAS No.

2563929-84-8

Appearance

Solid

Color

White to off-white

SMILES

[Bepirovirsen (sodium)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.44%

Select Batch: Data Sheet (268 KB)SDS (252 KB)

COA (245 KB)LCMS (348 KB)

Handling Instructions (2659 KB)

References

[1]. Yuen MF, et al. Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial. Nat Med. 2021 Oct;27(10):1725-1734.  [Content Brief]

[2]. Yuen MF, et al. Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection. N Engl J Med. 2022 Nov 24;387(21):1957-1968.  [Content Brief]

[3]. Han K, et al. Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses. Clin Pharmacol Drug Dev. 2022 Oct;11(10):1191-1202.  [Content Brief]

Bepirovirsen sodium Related Classifications

Infection

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2563929-84-8

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Bepirovirsen sodium Related Antibodies

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