20537-88-6

Product Details:

CasNo： 20537-88-6

Molecular Formula： C5H15N2O3PS

Purity： 99%

Synonyms: Ethyol; γphos; Fosteamine; 2-(3-Aminopropyl)aminoethyl phosphorothioate,WR2721; Ethiotas; S-2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate ester; Amifostine,2-(3-Aminopropyl)aminoethyl phosphorothioate,WR2721; AMifostine anhydrous

Melting point: 160-161 ºC

Boiling point: 441.7±51.0 °C

Density: 1.367±0.06 g/cm3
Solubility: Soluble in Water

Pka: 1.28±0.10
Form: Powder
Color: White

Water Solubility: Soluble to 100 mM in water

Description:

Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.

Uses:

It is a thiophosphate derivative of cysteamine; provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment.

Definition:

An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.