1132827-21-4
- Product Name：Quizartinib hydrochloride
- Molecular Formula：C29H33ClN6O4S
- Purity：99%
- Molecular Weight：597.13
Product Details:
CasNo： 1132827-21-4
Molecular Formula： C29H33ClN6O4S
Purity： 99%
Synonyms: AC 010220 (dihydrochloride); AC 220 dihydrochloride; Quizartinib dihydrochloride; Quizartinib HCl; 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea:dihydrochloride; AC-220; AC220; Quizartinib HCl (AC-220)
Description:
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis.
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