950769-58-1

Product Details:

CasNo： 950769-58-1

Molecular Formula： C29H32N6O4S

Purity： 99%

Synonyms: N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC-220; quizartinib(FLT3 inhibitor); CS-53; N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea; QUIZARTINIB (AC220); AC-220; AC220; QUIZARTINIB; 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-y
Density: 1.39±0.1 g/cm3
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Color: White to off-white
Form: Powder
Pka: 12.59±0.70
Storage temp.: -20°C
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Biological activity:
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 3.

In Vitro: 
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity high selectivity, but high selectivity when inhibiting most protein kinase of the human. AC220 is a new selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

In Vivo: 
In a xenograft tumor model, AC220 has nice drug attributes, good efficacy and high tolerability.. AC220 inhibits the activity of FLT3 and significantly extends survival in a mouse model of FLT3-ITD AML. Treatment with AC220 results in eradicating tumors in a xenograft tumor mouse model depended on FLT3. AC220 effectively inhibits the activity of FLT3 in primary cells of patients.

Features:
Quizartinib (AC220) is a 2nd-generation FLT3 inhibitor as the first clinical drug candidate.

Uses:
Quizartinib (AC220) is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).