472-15-1

Product Details:

CasNo： 472-15-1

Molecular Formula： C30H48O3

Purity： 99%

Synonyms: 3BETA-HYDROXY-20(29)-LUPENE-28-OIC ACID; 3BETA-HYDROXY-20(29)-LUPAENE-28-OIC ACID; 3B-HYDROXY-20(29)-LUPENE-28-OIC ACID; (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentaMethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid; Birch bark extract/β-Amyrin/betulinic acid; 3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID; BETULINIC ACID

Melting point: 295-298 °C (dec.) (lit.)
Alpha: D25 +7.5° (c = 0.37 in pyridine)
Boiling point: 550.0±33.0 °C
Density: 1.065±0.06 g/cm3
Refractive index: 7.8 ° (C=0.9, Pyridine)
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Pka: 4.61±0.70
Color: White or off-white
Optical activity: [α]20/D +7.8°, c = 0.9 in pyridine

Description:
Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.

Uses:
antineoplastic
Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity.
Betulinic acid (BetA) has been used:
1. To test its effects as an antiviral agent against Dengue virus (DENV).
2. As a sterol regulatory element-binding protein (SREBP) inhibitor to repress the lipid metabolism and proliferation of clear cell renal cell carcinoma (ccRCC) cells.
3. As a treatment to test its anti-tumor properties for cell viability and apoptotic cell death assays in multiple myeloma models.

Definition:
A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium cla iflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.

General Description:
Betulinic acid is a lupane-type triterpene, which can be prepared from betulin via oxidation using chromium oxide (VI). Along with anti-HIV-1 and anti-tumor activity, it also shows other bioactivities such as anti-inflammatory, antibacterial, in vitro antimalarial, anthelmintic and antioxidant activities.