157-03-9

Product Details:

CasNo： 157-03-9

Molecular Formula： C6H9N3O3

Purity： 99%

Synonyms: 6-diazo-5-oxo,l-norleucin; 6-diazo-5-oxo-l-norleucin; diazo-oxo-norleucine; don; 6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID; 6-DIAZO-5-OXO-L-NORLEUCINE; 6-DIAZO-5-OXO-NORLEUCINE; L-DON

Melting point: 145 °C
Boiling point: 301.12°C (rough estimate)
Density: 1.3994 (rough estimate)
Refractive index: 1.5800 (estimate)
Storage temp.: -20°C
Solubility: DMSO (Slightly, Heated, Sonicated), Water (Slightly)
Form: crystalline
Color: light yellow
Stability: Hygroscopic

Uses:
6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Definition:
6-diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. It has a role as a bacterial metabolite, an analgesic, an antibacterial agent, an antiviral agent, an antineoplastic agent, an EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor, an EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor, an EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor, an antimetabolite, a glutamine antagonist, an apoptosis inducer, an EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor, an EC 3.5.1.2 (glutaminase) inhibitor, an EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor and an EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor. It is a non-proteinogenic L-alpha-amino acid, a diazo compound and a ketone. It is a tautomer of a 6-diazo-5-oxo-L-norleucine zwitterion.

General Description: Chemical structure: amino acid derivatives

Biochem/physiol Actions:
DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.