ABT-199 is , while it's Molecular Formula is C45H50ClN7O7S. ABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.

What is the CAS number for ABT-199?

The CAS number of ABT-199 is 1257044-40-8.

What is ABT-199 (1257044-40-8) used for?

Venetoclax, codeveloped byAbbVie (previously Abbott Laboratories) and Genentech/Roche, was approved in the US for treatment of patients withchronic lymphocytic leukemia (CLL). To meet qualificationsfor venetoclax treatment, patients must have received priortherapy and possess the 17p deletion genetic mutation, asdetermined by USFDA testing. Venetoclax functions as aselective inhibitor of B cell lymphoma subtype 2 (BCL-2),which is often overexpressed on malignant cells and thus leadsto impairment of the apoptotic pathway. Along these lines,the orally dosed small molecule drug restores the ability ofmalignant cells to undergo apoptosis as its mechanism ofaction.90 Although other BCL-2 inhibitors are known, developmentof similar agents such as navitoclox have been pursuedand halted due to undesired inhibition of BCL-XL, leading tosignificant thrombocytopenia and demonstrating the need formore selective inhibitors. Venetoclax is also currently beingconsidered for approval in Europe and Canada for similarindications and is in various stages of development for thetreatment of non-Hodgkin lymphomas (NHL), acute myeloidleukemia (AML), multiple myeloma (MM), and several otherdisorders, either as a combination therapy or a stand-alonetreatment.

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1257044-40-8

Product Name：Venetoclax(ABT-199)
Molecular Formula：C45H50ClN7O7S
Purity：99%
Molecular Weight：868.454

Inquiry

Product Details:

CasNo： 1257044-40-8

Molecular Formula： C45H50ClN7O7S

Offer Quality Manufacturer Supply Venetoclax(ABT-199) 1257044-40-8 Customized Supply

Molecular Formula:C45H50ClN7O7S
Molecular Weight:868.454
PKA:4.09±0.10(Predicted)
PSA：183.09000
Density:1.340±0.06 g/cm3(Predicted)
LogP:10.73070

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