What is the Amikacin disulfate salt?

Amikacin disulfate salt is white, while it's Molecular Formula is C22H43N5O13 . 2(H2SO4). white Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.

What is the CAS number for Amikacin disulfate salt?

The CAS number of Amikacin disulfate salt is 39831-55-5.

What is the Amikacin disulfate salt?

Amikacin disulfate salt is white, while it's Molecular Formula is C22H43N5O13 . 2(H2SO4). white Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.

What is the CAS number for Amikacin disulfate salt?

The CAS number of Amikacin disulfate salt is 39831-55-5.

Product Class

39831-55-5

Product Name：Amikacin Sulphate
Molecular Formula：C₂₂H₄₃N₅O₁₃^.2(H₂SO₄)
Purity：99%
Molecular Weight：781.768

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Product Details:

CasNo： 39831-55-5

Molecular Formula： C₂₂H₄₃N₅O₁₃^.2(H₂SO₄)

Appearance： white

Factory Supply High Purity Amikacin Sulphate,Export 39831-55-5 Cheapest Price

Molecular Formula:C22H43N5O13^.2(H2SO4)
Molecular Weight:781.768
Appearance/Colour:white
Vapor Pressure:0mmHg at 25°C
Melting Point:220-230 °C
Boiling Point:981.8 °C at 760 mmHg
Flash Point:547.6 °C
PSA：497.90000
LogP:-4.37610

Amikacin disulfate salt(Cas 39831-55-5) Usage

Description	Amikacin Sulfate is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. It is primarily used for treating serious Gram-negative bacterial infections that are resistant to other antibiotics, including those caused by Pseudomonas aeruginosa, Proteus, and Serratia. Amikacin binds irreversibly to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis and leading to bacterial cell death.
Originator	Amikin,Bristol,US,1976
Uses	Amikacin is effective against Gram-negative pathogens causing pneumonia and other respiratory infections. Especially used in complicated or resistant urinary infections caused by bacteria like E. coli and Proteus. Amikacin has been used in chitosan-nanoparticle dressings to promote wound healing by inhibiting bacterial growth at the wound site. Amikacin contains fewer enzymatic sites vulnerable to bacterial resistance mechanisms, making it effective against strains resistant to other aminoglycosides like gentamicin, tobramycin, and kanamycin. This makes amikacin a valuable option in treating multi-drug-resistant infections. Huarong Pharm adheres to our vision, our mission, and our value, keeping abreast of the current trend and state-of-the-art science and technologies of the global biopharmaceutical industry to serve our clients to the utmost satisfaction. Our existing advantages have led to our in-depth services for the R&D of small molecule drug discovery.
FDA Approval and Brand Names	Approved by the FDA: 1976 Brand Name: Amikin® Other generic forms of amikacin sulfate are also available globally.
Side Effects and Toxicity	Nephrotoxicity: Amikacin, like other aminoglycosides, can cause kidney damage (nephrotoxicity), particularly in patients with pre-existing renal disease. Monitoring kidney function during treatment is essential. Ototoxicity: There is a risk of irreversible hearing loss (ototoxicity), especially with prolonged use or high doses. Patients may experience tinnitus or hearing impairment, which is usually related to the cumulative dose. Neuromuscular Blockade: Amikacin may exacerbate pre-existing neuromuscular conditions, leading to muscle weakness or respiratory issues. Injection Site Reactions: Local irritation or inflammation may occur at the injection site.

InChI:InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

39831-55-5 Relevant articles

Approaches to improve the association of amikacin sulphate to poly(alkylcyanoacrylate) nanoparticles

María J. Alonso , Cándida Losa , Pilar Calvo , JoséL. Vila-Jato

International Journal of Pharmaceutics Volume 68, Issues 1–3 , 1 February 1991, Pages 69-76

Owing to the low rate of association of polar drugs, such as amikacin sulphate, to hydrophobic carriers, e.g. poly(alkylcyanoacrylate) nanoparticles, several procedures have been investigated to improve the drug carrier capacity. The greatest improvement was noted with the covalent reaction between the drug and the suspension agent dextran 70, attached to the particle surface.

Electrochemical detection of amikacin sulphate using reduced graphene oxide and silver nanoparticles nanocomposite

Neha Sharma, Sathish Panneer Selvam, Kyusik Yun Ph.D.

Applied Surface Science Volume 512, 15 May 2020, 145742

This work reports the use of NiF-AgNPs/rGO for the detection of amikacin sulphate. The application of AgNPs from RC with a reduced rGO nanocomposite on NiF achieved better electrochemical detection of antibiotic.

39831-55-5 Upstream products

37517-28-5
amikacin

39831-55-5 Downstream products

37517-28-5
amikacin
1448168-07-7
3-C-azido amikacin

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