What is the Ondansetron hydrochloride?

Ondansetron hydrochloride is White crystal powder, while it's Molecular Formula is C18H24ClN3O3. White crystal powder Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.

What is the CAS number for Ondansetron hydrochloride?

The CAS number of Ondansetron hydrochloride is 103639-04-9.

What is Ondansetron hydrochloride (103639-04-9) used for?

Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the managementof nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reportedto have a superior side-effect profile compared with metoclopramide, representing animportant advance in the treatment of nausea and vomiting associated with chemotherapy.Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It isalso under investigation for a number of other indications, including anxiety andschizophrenia.InChI:InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

Product Class

103639-04-9

Product Name：Ondansetron Hcl
Molecular Formula：C₁₈H₂₄ClN₃O₃
Purity：99%
Molecular Weight：365.85

Inquiry

Product Details:

CasNo： 103639-04-9

Molecular Formula： C₁₈H₂₄ClN₃O₃

Appearance： White crystal powder

Buy High Grade Ondansetron Hcl,Offer 103639-04-9 Customized Supply

Molecular Formula:C18H24ClN3O3
Molecular Weight:365.85
Appearance/Colour:White crystal powder
Vapor Pressure:1.47E-12mmHg at 25°C
Melting Point:231-232oC
Boiling Point:546 °C at 760 mmHg
Flash Point:284 °C
PSA：58.28000
Density:1.27 g/cm³
LogP:3.80190

Ondansetron hydrochloride(Cas 103639-04-9) Usage

Category	Antiemetic drug, Serotonin (5-HT3) receptor antagonist
Definition	Ondansetron hydrochloride is a potent and selective 5-HT3 receptor antagonist used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and postoperative procedures. It works by blocking serotonin receptors in the gastrointestinal tract and the central nervous system, which prevents the emetic (vomiting) response.
Properties	Physical Appearance: White or almost white powder Mechanism of Action: Ondansetron hydrochloride blocks the action of serotonin (5-HT), a chemical that binds to 5-HT3 receptors in the brain and gastrointestinal tract, preventing the signals that trigger nausea and vomiting. Bioavailability: Ondansetron has poor bioavailability in conventional forms, often necessitating alternative delivery methods like nasal or transdermal formulations to improve patient compliance.
Uses	Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Nausea and Vomiting Prevention: Ondansetron hydrochloride is used to prevent and treat nausea and vomiting caused by: Chemotherapy (e.g., cisplatin, cyclophosphamide) Radiation therapy Postoperative procedures Potential Investigations: It is being studied for potential applications in managing nausea and vomiting related to other medical conditions and procedures, although more research is needed to confirm its efficacy in these areas.
Brand name	Zofran (GlaxoSmithKline);Zophran.
Therapeutic Function	Serotonin antagonist
Mode of Action	Serotonin Blockade: Ondansetron works by blocking serotonin receptors in the gastrointestinal tract and the central nervous system, specifically the 5-HT3 receptors. Serotonin is a key neurotransmitter involved in the emetic response, and by blocking its effects, Ondansetron prevents nausea and vomiting. Inhibition of the Emetic Response: The 5-HT3 receptors are involved in transmitting signals from the gut to the brain's vomiting center. By inhibiting these signals, Ondansetron effectively reduces the likelihood of nausea and vomiting triggered by chemotherapy or surgery.
Biochem/physiol Actions	5-HT3 serotonin receptor antagonist

InChI:InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

103639-04-9 Relevant articles

In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride

Marina Koland, R Narayana Charyulu, K Vijayanarayana,1 and Prabhakara Prabhu

Int J Pharm Investig. 2011 Jul-Sep; 1(3): 164–171.

The AUC and values of Cmax of ondansetron hydrochloride were found to be significantly greater (P < 0.005) than the selected films C2 and C3, as compared to those from the oral solution, thereby confirming improved bioavailability via the buccal route.

Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

Jadupati Malakar,1 Amit Kumar Nayak,2 and Aalok Basu1

International Scholarly Research Network ISRN Pharmaceutics Volume 2012, Article ID 428396, 6 pages

Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase,

Formulation and evaluation of niosomal vesicles containing ondansetron HCL for trans-mucosal nasal drug delivery

Mahmoud H. Teaima,Ahmed M. El Mohamady,Mohamed A. El-Nabarawi &Amir I. Mohamed

, Drug Development and Industrial Pharmacy, Volume 46, 2020 - Issue 5

Comparative in vivo pharmacokinetic study on rabbits showed a sustained release and higher relative bioavailability of the prepared nasal in situ gel compared to similar dose of oral tablets (202.4%) which make ondansetron HCl niosomal nasal thermo-sensitive in situ gel a more convenient dosage form for the administration of ondansetron HCl than oral tablets.

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