What is the Irinotecan hydrochloride?

Irinotecan hydrochloride is Yellow crystalline powder, while it's Molecular Formula is C33H38N4O6 . HCl. Yellow crystalline powder A DNA topoisomerase inhibitor

What is the CAS number for Irinotecan hydrochloride?

The CAS number of Irinotecan hydrochloride is 100286-90-6.

What is Irinotecan hydrochloride (100286-90-6) used for?

lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potentanticancer agent camptothecin, was launched in Japan for the treatment of lung,ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibitionof topoisomerase I, a cellular enzyme that is involved in maintaining the topographicstructure of DNA during the process of translation, transcription, and mitosis.lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38,which is 1000-fold more potent than the parent. Although being much less toxic thancamptothecin, a significant number of patients in clinical trials exhibited side effectsof leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy ofirinotecan with another widely used anticancer agent, cisplatin, has been reported tobe superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal,breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin'slymphoma.InChI:InChI=1/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

Product Class

100286-90-6

Product Name：Irinotecan Hcl
Molecular Formula：C₃₃H₃₈N₄O₆^.HCl
Purity：99%
Molecular Weight：623.149

Inquiry

Product Details:

CasNo： 100286-90-6

Molecular Formula： C₃₃H₃₈N₄O₆^.HCl

Appearance： Yellow crystalline powder

Buy Quality Irinotecan Hcl,Sale 100286-90-6 Safe Transportation

Molecular Formula:C33H38N4O6^.HCl
Molecular Weight:623.149
Appearance/Colour:Yellow crystalline powder
Vapor Pressure:1.31E-32mmHg at 25°C
Melting Point:250-256 ºC (dec.)
Refractive Index:67.7 ° (C=1, H2O)
Boiling Point:873.4 ºC at 760 mmHg
Flash Point:482 ºC
PSA：114.20000
LogP:4.76890

Irinotecan Hcl(Cas 100286-90-6) Usage

Irinotecan Hcl is a type of chemotherapy drug called a topoisomerase I inhibitor. It causes breaks that cannot be repaired in the DNA of cells. This stops the growth of cancer cells and other rapidly dividing cells and causes them to die. Irinotecan HCl is a chemotherapy drug used primarily in the treatment of colorectal cancer, particularly in cases where the cancer has metastasized or recurred. It is also used in combination with other chemotherapy agents to treat various solid tumors, including lung, gastric, and pancreatic cancers. Irinotecan works as a topoisomerase I inhibitor, interfering with the enzyme's ability to unwind DNA during replication, leading to DNA damage and ultimately cell death in rapidly dividing cancer cells. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm adheres to our vision, our mission, and our value, keeping abreast of the current trend and state-of-the-art science and technologies of the global biopharmaceutical industry to serve our clients to the utmost satisfaction. Our existing advantages have led to our in-depth services for the R&D of small molecule drug discovery.

InChI:InChI=1/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H/t33-;/m0./s1

100286-90-6 Relevant articles

Irinotecan hydrochloride is a pale yellow to yellow crystalline powder

Kumar V Kiran1, Raju N Appala2,*, Rani Namratha2, Rao JVLN Seshagiri3, Satyanarayana T2

, Asian Journal of Research in Chemistry, 2009, Volume : 2, Issue : 1

The percentage assay of Irinotecan HCl was 99.09%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Irinotecan HCl in bulk drug and in its pharmaceutical dosage form.

Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in Mice

Shigehiro Ohdo, Tomoko Makinosumi, Takashi Ishizaki, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano and Nobuya Ogawa

Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1383-1388;

The mechanisms underlying the circadian rhythm of the toxicity induced by irinotecan hydrochloride (CPT-11; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) were investigated from the viewpoint of the sensitivity of living organisms and the pharmacokinetics of the drug.

100286-90-6 Process route

: irinotecan carboxylate

: 100286-90-6
irinotecan hydrochloirde

Conditions

Conditions	Yield
With Britton-Robinson's buffer pH 6.0; water; at 37 ℃; Equilibrium constant; Kinetics; Thermodynamic data; E_a, A, var. pH, var. temp., var. time;

: 97682-44-5,130144-33-1
irinotecan

: 100286-90-6
irinotecan hydrochloirde