Product Class

15664-29-6

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CasNo： 15664-29-6

Molecular Formula： C35H36N4O5

Appearance： blue, to dark brown to black Solid

Delivery Time： 2 weeks after order

Throughput： 100KG/Month

Purity： 99%

Product Name:	Pheophorbide A
Synonyms:	PHEOPHORBIDE A;[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo;3-phorbinepropanoicacid,9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tet;[3S-(3alpha,4beta,21beta)]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionic acid;(3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;13-Epi-phaeophorbide-a;3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S)-;Inchi=1/C35H36N4o5/C1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/H8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/B22-12-,23-13-,24-12-,25-14-,26-13-,27-14-
CAS:	15664-29-6
MF:	C35H36N4O5
MW:	592.7
EINECS:	239-738-5
Product Categories:	Natural Porphyrins and Derivitives;Porphyrins;Elisa Kit-plant ELISA Kit
Mol File:	15664-29-6.mol

Pheophorbide A Chemical Properties

Melting point	191-195 °C
Boiling point	1019.0±65.0 °C(Predicted)
density	1.282±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: soluble0.5mg/mL, clear (warmed)
form	Solid
color	blue, to dark brown to black
Stability:	Light Sensitive
EPA Substance Registry System	3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)

Safety Information

MSDS Information

Pheophorbide A Usage And Synthesis

Uses	Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.
Uses	Pheophorbide-a has been used as a photosensitizer: for the photodynamic therapy (PDT) in oral cancer cell lines to test its effect on inducing oxidative stress and death in L. amazonensis to test its effect on the viability of HeLa cells
Definition	ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).
Biochem/physiol Actions	Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
Enzyme inhibitor	This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.

Pheophorbide A Preparation Products And Raw materials

Preparation Products