2376257-44-0
- Product Name：Bexotegrast
- Molecular Formula：C27H36N6O3
- Purity：99%
- Molecular Weight：492.61
Product Details:
CasNo： 2376257-44-0
Molecular Formula： C27H36N6O3
Appearance： White to off-white Solid
Delivery Time： 2 weeks after order
Throughput： 100KG/Month
Purity： 99%
Synonyms: Butanoic acid, 4-[(2-methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(4-quinazolinylamino)-, (2S)-; KR-39038; PLN74809; (S)-4-[(2-Methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(quinazolin-4-ylamino)butanoic Acid; Bexotegrast(PLN-74809); Butanoic acid, 4-[(2-methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(4-quinazolinylamino)
Boiling point: 769.7±60.0 °C
Density: 1.27±0.1 g/cm3
Pka: 3.08±0.10
Uses:
Bexotegrast is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung.
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