1075705-01-9
- Product Name：4-Fluoro-2-methoxy-5-nitroaniline
- Molecular Formula：C7H7FN2O3
- Purity：99%
- Molecular Weight：186.143
Product Details:
CasNo： 1075705-01-9
Molecular Formula： C7H7FN2O3
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- Molecular Formula:C7H7FN2O3
- Molecular Weight:186.143
- Melting Point:130 °C
- Boiling Point:354.8±37.0 °C(Predicted)
- PKA:2.31±0.10(Predicted)
- PSA：81.07000
- Density:1.412±0.06 g/cm3(Predicted)
- LogP:2.42910
4-Fluoro-2-methoxy-5-nitroaniline(Cas 1075705-01-9) Usage
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Description |
4-Fluoro-2-methoxy-5-nitroaniline is an organic compound with the molecular formula C7H7FN2O3. It contains a fluorine atom, a methoxy group (-OCH3), a nitro group (-NO2), and an amino group (-NH2), attached to a benzene ring. Appearance: Crystalline solid, typically yellowish in color. |
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Uses |
4-Fluoro-2-methoxy-5-nitroaniline is an organic chemical compound used as an intermediate in the synthesis of pharmaceuticals, particularly anticancer agents, and potentially in the production of dyes and agrochemicals. Due to its reactive functional groups, 4-Fluoro-2-methoxy-5-nitroaniline can be used in the synthesis of dyes, pharmaceuticals, or agrochemicals as a building block for complex organic molecules. Huarong Pharm has built platforms for the research, development and manufacturing of Building Blocks, Reference Compounds & Impurities, Natural products, APIs & Intermediates, Huarong Pharm adheres to our vision, our mission, and our value, keeping abreast of the current trend and state-of-the-art science and technologies of the global biopharmaceutical industry to serve our clients to the utmost satisfaction. Our existing advantages have led to our in-depth services for the R&D of small molecule drug discovery. |
| Safety and Handling | Toxicity: Like other nitroaniline derivatives, it may cause skin and eye irritation and can be harmful if inhaled or ingested. Precautions: Use personal protective equipment (PPE) such as gloves, safety goggles, and ensure proper ventilation. Avoid inhalation of dust or vapors and direct contact with skin and eyes. Environmental Impact: The nitro group and fluorinated compounds can be persistent in the environment, and care should be taken to prevent environmental contamination. |
1075705-01-9 Relevant articles
Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib
Manuel Köckinger, Benjamin Wyler, Christof Aellig, Dominique M. Roberge, Christopher A. Hone*, and C. Oliver Kappe*
, Org. Process Res. Dev. 2020, 24, 10, 2217–2227
The development of a scalable telescoped continuous flow procedure for the acetylation and nitration of 4-fluoro-2-methoxyaniline is described. A subsequent batch deprotection then affords 4-fluoro-2-methoxy-5-nitroaniline, a key building block in the synthesis of osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that is used for the treatment of nonsmall-cell lung carcinomas carrying EGFR-TKI sensitizing and EGFR T790M resistance mutations.
Improvements in the Synthesis of the Third-Generation EGFR Inhibitor Osimertinib
Pinelopi Voulgari, Dimitrios Alivertis, Konstantinos Skobridis
, Helvetica Chimica Acta, Volume104, Issue11 November 2021 e2100066
… the hydrochloride salt of 4-fluoro-2-methoxy-5-nitroaniline (6) … commercially available 4-fluoro-2-methoxy-5-nitroaniline (6) … dried to give quantitatively 4-fluoro-2-methoxy-5-nitroaniline …
Compound for inhibiting three-mutant epidermal growth factor receptor tyrosine kinase and application thereof
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Paragraph 0039; 0073; 0074; 0078-0080, (2021/09/15)
A core building block in the synthesis of 1 is a tetrasubstituted benzene ring that is derived from 4-fluoro-2-methoxy-5-nitroaniline (2) (Scheme 1). Compound 2 can be prepared by the …
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