16846-24-5

Product Details:

CasNo： 16846-24-5

Molecular Formula： C42H69NO15

Appearance： white to slightly yellow powder

Delivery Time： 2 weeks after order

Throughput： 100KG/Month

Purity： 99%

Synonyms: Vilprafen; Wilprafen; 3-Acetate 4B-(3-Methylbutanoate)leucoMycin V; LeucoMycin V, 3-acetate 4B-(3-Methylbutanoate); Leucomycin V 3-acetate 4''-(3-methylbutanoate)
Alpha: D25-70° (c = 1 in ethanol)
Boiling point: 763.27°C
Density: 1.1547 g/cm3
Refractive index: 1.6220
Flash point: 484.7±34.3 °C
Solubility: Soluble in ethanol
Pka: 7.1 (40% aq methanol)
Stability: Hygroscopic
Vapor pressure: 0.0±0.6 mmHg at 25°C

Chemical Properties:
Josamycin is a macrolide substance having antibacterial activity produced by the growth of Streptomyces narboensis var. josamyceticus.
Josamycin is very soluble in methanol or in ethanol, and very slightly soluble in water.

Uses:
As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.
Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Therapeutic Function: Antibiotic

Biological Activity:
Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.