155030-63-0

  • Product Name:Emodepside
  • Molecular Formula:C60H90N6O14
  • Purity:99%
  • Molecular Weight:1119.39
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Product Details:

CasNo: 155030-63-0

Molecular Formula: C60H90N6O14

Appearance: White to off-white Solid

Delivery Time: 2 weeks after order

Throughput: 100KG/Month

Purity: 99%

Synonyms: Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl; Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzeneprop; PF 1022-221; Bay 44-4400; Cyclo[(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]; (3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-tetraisobutyl-4,6,10,16,18,22-hexamethyl-12,24-bis(4-morpholinobenzyl)-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octaone
Boiling point: 1219.3±65.0 °C
Density: 1.104±0.06 g/cm3
Solubility: DMSO : ≥ 31 mg/mL (27.69 mM)
Pka: 5.34±0.40

 

Uses: Emodepside-d6 is an isotopic labeled compound of Emodepside; an anthelmintic drug very active against gastrointestinal nematodes.

 

Definition:
A cyclooctadepsipeptide consisting of D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, N-methyl-L-leucyl, D-lact yl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, and N-methyl-L-leucyl residues joined in sequence to give a 24-membered macrocycle. An anthelmintic, it i used with praziquantel for the treatment and control of hookworm, roundworm and tapeworm infections in cats.

 

Biological Activity:
Emodepside is a cyclooctadepsipeptide anthelmintic a novel mode of action involving the calcium-gated potassium channel SLO-1 in C. elegans, sometimes mediated by a latrophilin (LAT) receptor.

 

Veterinary Drugs and Treatments:
Emodepside/Praziquantel topical solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.

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