796073-69-3

Product Details:

CasNo： 796073-69-3

Molecular Formula： C38H54ClN3O10S

Appearance： White to Light Yellow Solid

Delivery Time： 2 weeks after order

Throughput： 100KG/Month

Purity： 99%

Synonyms: N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine; Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-; Mertansine Impurity 1; N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4); Benzoicacid,5-(chlorosulfonyl)-4-methyl-; Ravtansine
Boiling point: 943.2±65.0 °C
Density: 1.29±0.1 g/cm3
Solubility: DMSO: 100 mg/mL (128.14 mM)
Pka: 9.82±0.70

Structure:
Structurally, maytansinoid derivatives DM1, DM3, and DM4 differ based on the number of methyl groups present on the carbon adjacent to sulfur—zero, one, or two, respectively. The introduction of methyl groups contributes to the heightened potency of the free drug, likely due to increased hydrophobicity and improved membrane permeability. DM4 is a thiol-containing compound that undergoes methylation within cells through the activity of methyltransferases, forming S-Me-DM4. This metabolite demonstrates notable cytotoxicity. Importantly, both DM4 and S-Me-DM4 can pass through cell membranes, leading to an enhanced phenomenon known as the "bystander effect," where the drug can diffuse out of a targeted cell into adjacent cells.

Description:
Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs).M4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

Uses: 
DM4 is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.