434-13-9
- Product Name：LITHOCHOLIC ACID
- Molecular Formula：C24H40O3
- Purity：99%
- Molecular Weight：376.57
Product Details:
CasNo： 434-13-9
Molecular Formula： C24H40O3
Appearance： White to Off-White Powder
Delivery Time： 2 weeks after order
Throughput： 100KG/Month
Purity： 99%
Synonyms: 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol; 17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol; BETA-CHOLANIC ACID-3-ALPHA-OL; HYDROYCHOLANIC ACID; 3-HYDROXYCHOLANIC ACID; 3ALPHA-HYDROXYCHOLANIC ACID; 3ALPHA-HYDROXY-5BETA-CHOLANIC ACID; 3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID
Alpha: D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
Boiling point: 445.09°C
Density: 1.0454 g/cm3
Refractive index: 35.5 ° (C=1, EtOH)
Fp: 9℃
Solubility: Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated)
Pka: 4.76±0.10
Optical activity: +3220 (c 1.5, ethanol)
Biological source: bovine bile synthetic
Water Solubility: 18.83ug/L(25 ºC)
Uses:
A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
Anticholelithogenic.
Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.
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