121808-62-6

Product Details:

CasNo： 121808-62-6

Molecular Formula： C9H12N2O4S

Purity： 99%

Synonyms: (4R)-3-[(2S)-5-Oxopyrrolidine-2-carbonyl]-1,3-thiazolidine-4-carboxylic acid; Adimod; (4S)-3-(5-Oxo-L-prolyl)thiazolidine-4-carboxylic acid; 3-Pyroglutamoylthiazolidine-4-carboxylic acid; (4R)-3-[(2S)-5-ketopyrrolidine-2-carbonyl]thiazolidine-4-carboxylic acid; (4R)-3-[(2S)-5-oxopyrrolidin-2-yl]carbonyl-1,3-thiazolidine-4-carboxylic acid; 3-L-pyroglutaMyl-L-thiazolidine-4-carboxylic acid; (R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid

Melting point: 194-198°C (dec.)

Boiling point: 663.0±55.0 °C at 760 mmHg

Density: 1.53 g/cm3

Refractive index: 1.619

Form: Powder

Color: White to beige

Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), 5N HCl (Slightly)

Pka: 3.03 (at 25℃)

Optical activity: [α]/D -135 to -155°, c = 1 in 6 M HCl

Flash point: 354.8±31.5 °C

Water Solubility: H2O: 2mg/mL, clear (warmed)

Alpha; D25 -150° (c = 2 in 5N HCl)

Description:

Pidotimod, a dipeptide immunomodulating agent, has been introduced as immunostimulant therapy in patients with cell-mediated immunosuppression during respiratory or urinary tract infections. Its mode of action on the immune system is by activation of T-lymphocytes via interleukin (IL)-2 stimulation and macrophages via activation of superoxide dismutase and chemotaxis. In mice, treatment with pidotimod causes significant increase in the natural killer cell activity that may play an important role in immunosurveillance against tumors and in physiological homeostasis. Pidotimod can reverse the immunosuppression caused by surgical stress and has antiinflammatory, antioxidant, and antiaging properties. It has also been reported to provide protection from bacterial infections in mice.

Uses:

Immunostimulant used in patients with cell-mediated immunodepression.