88678-31-3

Product Details:

CasNo： 88678-31-3

Molecular Formula： C18H20N2O2S

Purity： 99%

Synonyms: LNF; O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate; carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na phthalenyl)ester; LIRANAFATE; M-732; (6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER

Melting point: 98.5-99.5°C

Boiling point: 462.5±55.0°C

Density: 1.240±0.06 g/cm3

Pka: 1.24±0.10

Solubility: DMSO (Slightly), Methanol (Slightly, Heated)

Form: Solid

Color: Off-White

Description:
Liranaftate is a new king of third-generation dithiocarbamate antifungals , it is a new kind of the third category of chemicals,it belongs to squalene cyclooxygenase inhibitors, by inhibiting the fungal cell membrane squalene epoxidation reaction , it hinders the synthesis of ergosterol which is a constituent of cell membranes ,it plays the role of anti-fungal,its anti-fungal activity is 8 times of tolnaftate, and its dermatophytes effect is better than clotrimazole.  It has a strong anti-fungal effect on skin filamentous fungi (Trichophyton,Microsporon, Epidermophyton) , it also shows antifungal activity on other filamentous fungi, dark fungi, dimorphic fungi. It is useful in the treatment of tinea capitis, ringworm, athlete's foot, tinea pedis, onychomycosis, tinea, jock itch, tinea versicolor and vulvovaginal candidiasis.

Uses:

A squalene epoxidase inhibitor. Used as an antifungal.

Broad-spectrum antifungal.