516-55-2

Product Details:

CasNo： 516-55-2

Molecular Formula： C21H34O2

Purity： 99%

Synonyms: ALLOPREGNANOLONE; 3-beta-allopregnanolone; 3-beta-hydroxy-5-alpha-pregnan-20-on; 3-hydroxy-,(3-beta,5-alpha)-pregnan-20-on; 3-Hydroxypregnan-20-one; 5alpha-Pregnan-20-one,3beta-hydroxy-; 5alpha-Pregnane-3beta-ol-20-one; Allopregnan-3beta-ol-20-one; Allopregnane-3beta-ol-20-one

Melting point: 200ºC

Boiling point: 431.2±18.0 °C

Alpha: D27 +91.2° (c = 0.4 in ethanol)

Density: 1.1 g/cm3

Solubility: Chloroform (Slightly), Methanol (Slightly)

Pka: 15.12±0.70

Form: Solid

Color: White to Off-White

Description:

3-β-Hydroxy-5-α-pregnan-20-on (Allopregnanolone) is a neuroactive metabolite of progesterone. It is a potent positive allosteric modulator of the action of GABA on the GABAA receptor.

Biological functions:
Allopregnanolone mediates its effects through modulation of the GABAA receptor. Allopregnanolone is reported to modulate the GABA-ergic function by increasing the GABAA receptor opening frequency and duration of the receptor at concentrations in the nanomolar range.  A balance between unbinding, desensitization, and reopening of the desensitized GABAA receptor underlies the delay of the inhibitory postsynaptic currents.  Allopregnanolone slows the rate of recovery of the GABAA receptor from desensitization and possibly increases the rate of entry into fast desensitized states.  Allopregnanolone exerts neurogenetic, neuroprotective, antidepressant, and anxiolytic effects.  Reduced levels of allopregnanolone are found to be associated with major depression, anxiety disorders, premenstrual dysphoric disorder, and Alzheimer’s disease.  Allopregnanolone is actively produced in the pineal gland compared with the brain and pineal allopregnanolone acts on Purkinje cells to prevent apoptosis in the juvenile quail.

Uses:

3-β-Hydroxy-5-α-pregnan-20-on (Allopregnanolone) is a progesterone with anesthetic, hypnotic, and sedative effects that can interfere with the rapid tolerance of ethanol's anti anxiety effects.