18621-18-6
- Product Name：3-Hydroxyazetidine hydrochloride
- Molecular Formula：C3H8ClNO
- Purity：99%
- Molecular Weight：109.55
Product Details:
CasNo： 18621-18-6
Molecular Formula： C3H8ClNO
Purity： 99%
Synonyms: 3-AZETIDINOL HYDROCHLORIDE; 3-HYDROXYAZETIDINE HCL; AZETIDIN-3-OL HYDROCHLORIDE; AZETIDIN-3-OL, HYDROCHLORIDE SALT; 3-hydroxyazacyclobutane hydrochloride; AZETAN-2-ONE
Melting point: 85-90 °C
Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Form: Solid
Color: White to Off-White
Water Solubility: Soluble in water, DMSO, methanol
Sensitive: Hygroscopic
Stability: Hygroscopic
Description:
3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.
Uses:
3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.
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