69975-86-6

Product Details:

CasNo： 69975-86-6

Molecular Formula： C11H14N4O4

Purity： 99%

Synonyms: DOXOPHYLLINE; 2-(7'-teofillinmetil)-1,3-diossolano; Doxofyliine; 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-purine-2,6-dione; DOXOFYLLINE[7-(1,3-DIOXOLAN-2-YLMETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE]; MAXIVENT; Ansirnar

Melting point: 144-146°C

Boiling point: 409.46°C

Density: 1.2896

Refractive index: 1.6000

Solubility: DMSO (Slightly), Methanol (Slightly)

pka: 0.42±0.70

Form: Solid

Color: White to off-White

Water Solubility: Soluble

Description:

Doxofylline is a methylxanthine bronchodilator that has been examined in clinical trials involving patients with either bronchial asthma or chronic obstructive pulmonary disease. Its mechanism of action is related to its ability to inhibit phosphodiesterase activity and, thus, increase cAMP. Compared to other xanthine derivatives, which have direct arrhythmogenic effects, doxofylline demonstrates decreased affinity towards adenosine A₁ and A₂ receptors, does not interfere with calcium influx into cells, and does not antagonize the action of calcium-channel blockers.

Uses:

Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.

Definition:
Doxofylline is an oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. It has a role as a bronchodilator agent, an antitussive and an anti-asthmatic drug. It is functionally related to a 7H-xanthine.