14976-57-9

Product Details:

CasNo： 14976-57-9

Molecular Formula： C25H30ClNO5

Purity： 99%

Synonyms: (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro; (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli; (+)-lfumarate; 1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine; (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE; 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine

alpha: D21 +16.9° (methanol)

Boiling point: 154 °C

Solubility: DMSO: soluble5mg/mL (clear solution; warmed)

Form: powder
Color: white to beige

Uses:

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.

Definition:

The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin condi ions.

Therapeutic Function:

Antihistaminic

Biological Activity:

H1-receptor antagonist. Clinically-used antihistamine.
 

Biochem/physiol Actions:

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.