What is the Risperidone?

Risperidone is crystalline solid, while it's Molecular Formula is C23H27FN4O2. crystalline solid A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist

What is the CAS number for Risperidone?

The CAS number of Risperidone is 106266-06-2.

What is Risperidone (106266-06-2) used for?

Risperidone is a novel antipsychotic introduced for the treatment of acute and chronicschizophrenia. It has a balanced serotonin 5-HT2 and dopamine D2 receptor antagonistactivity. While the anti-D2 activity may relate to the antipsychotic potency of neurolepticagents, an antidepressive efficacy of substances with anti-5-HT2 activity has beensuggested. Risperidone, therefore, has therapeutic action on both positive and negativesymptoms of schizophrenia and produces significantly fewer side effects especiallyextrapyramidal symptoms compared with commonly used pure D2 antagonist antipsychotics.It also has potential for management of alcohol withdrawal and cocaine addiction.InChI:InChI=1/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

Product Class

106266-06-2

Product Name：Risperidone
Molecular Formula：C₂₃H₂₇FN₄O₂
Purity：99%
Molecular Weight：410.491

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Product Details:

CasNo： 106266-06-2

Molecular Formula： C₂₃H₂₇FN₄O₂

Appearance： crystalline solid

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Molecular Formula:C23H27FN4O2
Molecular Weight:410.491
Appearance/Colour:crystalline solid
Vapor Pressure:4.14E-13mmHg at 25°C
Melting Point:170 °C
Refractive Index:1.676
Boiling Point:572.4 °C at 760 mmHg
PKA:pKa 8.3 (Uncertain)
Flash Point:300 °C
PSA：64.16000
Density:1.383 g/cm³
LogP:3.52830

Risperidone(Cas 106266-06-2) Usage

Description	Risperidone is categorized as a second-generation antipsychotic (SGA), also known as an atypical antipsychotic. Risperidone is an antipsychotic medication that modulates neurotransmitters in the brain, primarily dopamine and serotonin, to regulate mood, behavior, and thought processes. It works by antagonizing both 5-HT2A serotonin receptors and D2 dopamine receptors, reducing symptoms like hallucinations, delusions, and mood disturbances.
Uses	Risperidone blocks dopamine D1 and D2 receptors (specifically in the mesolimbic pathway) and serotonin 5-HT2A receptors, which is thought to reduce psychotic symptoms while minimizing side effects such as movement disorders. It is widely used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, and irritability associated with autism spectrum disorder (ASD). Risperidone can lead to hyperprolactinemia (elevated prolactin levels), which can cause symptoms like lactation, menstrual irregularities, and fertility issues. It also has sedative and weight-gain-inducing properties.
Originator	Janssen (U.S.A.)
Definition	ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Brand name	Risperdal (Janssen).
Clinical Concerns	Hyperprolactinemia (HPL): A common side effect of Risperidone, leading to elevated prolactin levels, which can affect somatic functions such as fertility and menstrual regularity. Managing hyperprolactinemia is essential for maintaining patient compliance with therapy, as discontinuation due to side effects can lead to worsening symptoms and hospitalization. Metabolic and Neurological Side Effects: Weight gain, sedation, and extrapyramidal symptoms (movement disorders) are possible but less common compared to first-generation antipsychotics.

InChI:InChI=1/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

106266-06-2 Relevant articles

Risperidone A Review of its Pharmacology and Therapeutic Potential in the Treatment of Schizophrenia

Susan Grant & A. Fitton

, Drug Evaluation, Volume 48, pages 253–273, (1994)

Risperidone exhibits central serotonin 5-HT2 and neostriatal dopamine D2 antagonistic activity, but is devoid of anticholinergic activity, in several in vivo animal models. It is also effective in animal behavioural models considered predictive of antipsychotic activity (e.g. suppression of apomorphine- and amphetamine-induced stereotypy and conditioned avoidance behaviour).

Risperidone Induced Hyperprolactinemia: From Basic to Clinical Studies

M Stojkovic, B Radmanovic, M Jovanovic

, Front. Psychiatry, 06 May 2022

General recommendations for Risperidone-related HPL include discontinuation or dose reduction, switching to a prolactin-sparing drug, adding dopamine agonists, or replacing estrogen in women. Several atypical APs with lower potential to block the D2 receptor have potentially more harmful long-term effects than Risperidone.

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