1442472-39-0
- Product Name：Ripretinib
- Molecular Formula：C24H21BrFN5O2
- Purity：99%
- Molecular Weight：510.36
Product Details:
CasNo： 1442472-39-0
Molecular Formula： C24H21BrFN5O2
Purity： 99%
Synonyms: KIT/PDGFR inhibitor(DCC2618); KIT/PDGFR INHIBITOR(DCC-2618); Ripretinib (DCC-2618); DCC-2618; DCC 2618; DCC2618; RIPRETINIB; KIT/PDGFR INHIBITOR; KIT/PDGFR inhibitor; N-[4-Bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenylurea
Boiling point: 568.6±50.0 °C
Density: 1.544±0.06 g/cm3
Solubility: DMSO:25.0(Max Conc. mg/mL); 49.0(Max Conc. mM)
Pka: 12.15±0.70
Form: Solid
Color: White to light yellow
Storage temp.: Store at -20°C
Uses:
Ripretinib is used in the treatment of gastrointestinal stromal tumors (GISTs).
Biological Activity:
Ripretinib is a highly effective inhibitor of both wild-type KIT and PDGFRA, with IC50 values around 3 nM. It also targets a wide range of KIT and PDGFRA mutants in GIST. Additionally, it inhibits various tumor-driving kinases such as PDGFRβ, TIE2, VEGFR2, and BRAF.
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