2152628-33-4
- Product Name：Selpercatinib
- Molecular Formula：C29H31N7O3
- Purity：99%
- Molecular Weight：525.6
Product Details:
CasNo： 2152628-33-4
Molecular Formula： C29H31N7O3
Purity： 99%
Synonyms: CPD2206; LOX-292; LOXO-292; LOXO292; LOXO 292; LOXO-292,Selpercatinib; Selpercatinib(LOXO-292); Pyrazolo[1,5-a]pyridine-3-carbonitrile,6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-; Saracatinib(AZD0530); Saracatinib
Density: 1.36±0.1 g/cm3
Solubility: DMSO: 20.0(Max Conc. mg/mL); 38.05(Max Conc. mM)
Pka: 14.00±0.29
Color: White to off-white
Form: A crystalline solid
Storage temp.: Store at -20°C
Binding Mode:
In the co-crystal structure of selpercatinib-RET kinase, the pyrazolopyridine occupies the adenosine pocket, forming a direct hydrogen bond between N1 and amide NH of Ala807 and an indirect hydrogen bond between C6 ether oxygen and amide NH of Gly810 via a bound water molecule. In addition, one piperazine nitrogen also interact with one water molecule.
Uses:
Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").
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